Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles

Post time 2024-4-23 14:42:30

journal：Journal of Medicinal Chemistry

Authors：Salma M. Hefny; Tarek F. El-Moselhy; Nabaweya El-Din; Simone Giovannuzzi; Thamer Bin Traiki; Mansoor-Ali Vaali-Mohammed; Ahmed M. El-Dessouki; Koki Yamaguchi; Masaharu Sugiura; Moataz A. Shaldam; Claudiu T. Supuran; Maha-Hamadien Abdulla; Wagdy M. Eldehna; Haytham O. Tawfik

Published date：--

DOI：10.1021/acs.jmedchem.4c00239

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00239

Article link：http://dx.doi.org/10.1021/acs.jmedchem.4c00239

Article Source：American Chemical Society (ACS)。

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Post time 2024-4-23 14:42:31

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[ACS] Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles

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[ACS] Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles