Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers

Post time 2024-5-7 19:49:48

journal：Journal of Medicinal Chemistry

Authors：Aoxue Wang; Wen Shuai; Chengyong Wu; Junping Pei; Panpan Yang; Xin Wang; Shutong Li; Jiaxi Liu; Yuxi Wang; Guan Wang; Liang Ouyang

Published date：2024-2-22

DOI：10.1021/acs.jmedchem.3c01934

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01934

Article link：http://dx.doi.org/10.1021/acs.jmedchem.3c01934

Article Source：American Chemical Society (ACS)。

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[ACS] Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers

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[ACS] Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers