Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS

Post time 2024-1-7 00:51:37

journal：Nature Cancer

Authors：Yuta Adachi; Ryo Kimura; Kentaro Hirade; Shogo Yanase; Yuki Nishioka; Natsumi Kasuga; Rui Yamaguchi; Hiromichi Ebi

Published date：--

DOI：10.1038/s43018-023-00575-2

PDF link：https://www.nature.com/articles/s43018-023-00575-2.pdf

Article link：http://dx.doi.org/10.1038/s43018-023-00575-2

Article Source：Springer Science and Business Media LLC。

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Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS

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Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS