Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Post time 2021-12-13 06:23:28

journal：Science Translational Medicine

Authors：Afroditi Katsarou; Maria Sjostrand; Jyoti Naik; Jorge Mansilla-Soto; Dionysia Kefala; Georgios Kladis; Alexandros Nianias; Ruud Ruiter; Renée Poels; Irene Sarkar; Yash R. Patankar; Elena Merino; Rogier M. Reijmers; Kristine A. Frerichs; Huipin Yuan; Joost de Bruijn; Dina Stroopinsky; David Avigan; Niels W. C. J. van de Donk; Sonja Zweegman; Tuna Mutis; Michel Sadelain; Richard W. J. Groen; Maria Themeli

Published date：2021-12-8

DOI：10.1126/scitranslmed.abh1962

Article link：http://dx.doi.org/10.1126/scitranslmed.abh1962

Article Source：American Association for the Advancement of Science (AAAS)。

Post time 2021-12-13 06:23:29

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[AAAS] Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

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